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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 2
First page : ( 177) Last page : ( 184)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00032.3

Study of The Protective Effect of Vitamin C plus E on Lincomycin-Induced Hepatotoxicity and Nephrotoxicity

Dr. Jwad Saher Mahmood1,*, Dr. Abbas Bushra1, Dr. Jaffat Haider S.2

1Biology Department, Faculty of Education for Girls, Kufa University, Iraq

2Biology Department, Faculty of Science, Kufa University, Iraq

*Corresponding Author E-mail: saher.m@yahoo.com

Abstract

The objective of the present study was to compare the beneficial effects of vitamins C and E on Lincomycin-induced hepatotoxicity and nephrotoxicity. Sixteen of male albino rats sexually matured were randomly divided into four groups: (i) control, (ii) Lincomycin (500 mg/kg) administrated orally, (iii) Lincomycin plus vitamin C (500 mg/kg) and vitamin E (400 mg/kg), (iv) vitamin C plus vitamin E were administrated orally at the same doses of third group. Lincomycin treatments were started directly (1) day after the first administrations of these vitamins and continued for (21) days. At the end of the experiments: body weight, liver, kidney and spleen relative weights, erythrocytes sedimentation rate, urea, total bilirubin, creatinine, malondialdehyde, glutathione, total cholesterol, triglycerides, low density lipoproteins, liver enzyme activities ALP, AST and ALP were significantly increased (p <0.05) in Lincomycin treated group, while haemoglobin concentration, packed cell volume, white blood cell counts, high density lipoproteins were significantly decreased (p <0.05) in the same group when compared with the three other groups: control, vitamins,Lincomycin and vitamins groups. Vitamins C and vitamin E were suppressed the oxidative stress of Lincomycin which used in this study, so the data of the present study suggest that, vitamin C and vitamin E could be useful for reducing the detrimental effects of Lincomycin-induced toxicity on liver and kidneys.

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Keywords

Vitamins C and E, Lincomycin, Physiological properties, Biochemical properties, Liver enzymes.

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