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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 12
First page : ( 1645) Last page : ( 1648)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00296.6

Exploring the in-vitro anthelmintic potential of Hydrolea zeylanica-An aquatic medicinal herb

Qureshi Mohammad Shamim1,*, Kumar G.S.2, Reddy A. Venkateshwar1

1Research Scholar, Department of Pharmacognosy, JNTUH, Kukatpally-50035, Hyderabad, Telangana, India

3Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad-500001, Telangana, India

2School of Pharmacy, International Medical University, Bukit Jallil, Kuala Lumpur, 57000, Malaysia

*Corresponding Author E-mail: sports78@gmail.com

Online published on 1 January, 2016.

Abstract

Development of anthelmintic drug resistance and the high cost of conventional anthelmintic drugs are led to the evaluation of medicinal plants as an alternative source of anthelmintic. The present study was undertaken to evaluate anthelmintic activity of aqueous (AE) and methanolic (ME) extracts of whole plant of Hydrolea zeylanica (L) against Pheretima posthuma. Various concentrations (25–100 mg/ml.) of aqueous and methanolic extracts were evaluated forthe bioassay involving determination of time of paralysis (P) and time of death (D) of the worms. Albendazole(Std.) was used as standardanthelmintic drug and distilled water was used as control. The results of present study indicated that the methanolic and aqueous extractssignificantly exhibited paralysis (P<0.05) in worms in lower doses (25, 50 and 100mg/ml) and also caused death of the worms especially at higherconcentration of 100 mg/ml, as compared to standard drug. The data were verified as statistically significant by using one way ANOVA at 5% level of significance (p < 0.05). Further studies are in process to isolate the active principles responsible for theanthelmintic activity.

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Keywords

Hydrolea zeylanicaPheretima posthuma, extracts, anthelmintic, Albendazole.

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