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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 10
First page : ( 1389) Last page : ( 1393)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00249.8

Formulation and in vitro comparative evaluation of orodispersible tablets of Pantoprazole

Srinivasa DS1, Charyulu Narayana R, Satyanarayana DS, Srilakshmi D

1Department of Pharmaceutics, Vikas institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, 533102, India

Nitte University, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Mangalore, Karnataka-575 018, India

Corresponding Author E-mail:

Online published on 2 December, 2015.

Abstract

In the present work, an attempt has been made to formulate oral dispersible tablets of pantoprazole by three different methods. Conventional tabletting procedure was followed for the preparation of tablets. Nine batches of tablets were prepared and evaluated for general appearance and physical parameters, drug content, in vitro disintegration, in vitro dispersion, in vitro drug release, kinetic and stability studies. Formulations prepared by superdisintegrants addition method emerged as the best formulations, as they showed rapid in vitro disintegration time, in vitro dispersion time and drug release at the end of 5 min, apart from taste and excellent mouth feel compared to formulations prepared by sublimation and effervescent methods. It was concluded that oral dispersible tablets of pantoprazole can be successfully formulated and will be used as a novel drug dosage form for pediatrics and geriatrics with improved patient compliance.

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Keywords

Pantoprazole; Orodispersible tablets; Superdisintegrants; Effervescent; Sublimation.

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