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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 1
First page : ( 35) Last page : ( 37)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00007.4

Improved Pharmacokinetic Parameters of Acyclovir in Rats

Kothule Kishore Uttam*, Gidwani Suresh Kumar, Gide Paraag

Jawaharlal Nehru Technological University, Hyderabad, India

*Corresponding Author E-mail: kothule@rediffmail.com

Abstract

The purpose of the present investigation is to develop and characterize Acyclovir oral suspension in which Acyclovir is present in nanoparticle form manufactured using chitosan through ionic gelation method and test oral bioavailability in Rats. Methods of manufacturing and characterization of Chitosan nanoparticles of acyclovir was previously discussed. In continuation to earlier research work acyclovir nanoparticles were incorporated in oral suspension dosage form. Finished oral nanosuspension was characterized and pharmacokinetic parameters were studied in Rats. Pharmacokinetic parameters of nano suspension were compared with pharmacokinetic parameters of marketed suspension. Improvement in Cmax and AUC values revealed improvement in absorption of acyclovir in Rats.

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Keywords

Nanoparticles, Acyclovir, Chitosan, Ionic gelation method, Nano suspension.

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