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Research Journal of Pharmacy and Technology
Year : 2015, Volume : 8, Issue : 1
First page : ( 27) Last page : ( 30)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2015.00005.0

Screening of Active Pharmaceutical Ingredients using Methanolic Leaf Extract of C. papaya L. against Hospital Acquired MDR Uropathogens

Upgade Akhilesh1,*, Prabhakaran P2

1Centre for Research and Development, PRIST University, Thanjavur, Tamilnadu

2Department of Microbiology, Marudupandiyar College, Vallam Thanjavur, Tamilnadu

*Corresponding Author E-mail: akhiupgade@gmail.com

Abstract

Emergence of specific infections associated with hospitals is special concern as per the recent reviews. As far as, there is uncontrolled population growth responsible for such a conditions. Managing diseases in tertiary care hospital including Government hospital, Private hospitals, mother care homes etc is tedious task. Nosocomial infections caused by the gram negative organisms to the admitted patients of all group occurs. Urine tract infection is one of the most threaten condition those admitted not only that they are multidrug resistant bugs which can difficult to manage. Hence, this study involves medicinally important plant to evaluate the antibacterial effect of plant on selected UTI causing bacteria like Pseudomonas aeruginosa, Klebsiella pneumoniae and E.coli. Traditional methods have been employed to check activity of methanolic extract C. papaya. The multi benefit plant in ancient literature describes about seeds and fruit effectively hence leaves has taken into accounts to accelerate scope of research. In results, the extract shows different antibacterial activity which was confirmed by measuring zone of inhibition as compare to standard antibiotic. E.coli and K. pneumonia was found most sensitive against plant extract and found more effective than antibiotic like Cef: Cefpodoxime, Chlor: Chloramphenicol, Ceftri: Ceftriaxone i.e. 27mm and 30 mm

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Keywords

C. papaya, Uropathogens, Nosocomial infections, MDR, UPEc.

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