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Research Journal of Pharmacy and Technology
Year : 2012, Volume : 5, Issue : 5
First page : ( 687) Last page : ( 690)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

In-vitro quality control measurement of some commercially available sustained release tablet containing diclofenac sodium

Giri Tapan Kumar*, Sahu Ravikant, Kumar Kulesh, Alexander Amit,  Ajazuddin, Badwaik Hemant, Tripathi Dulal Krishna

Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491024, India.

*Corresponding Author E-mail: tapan_ju01@rediffmail.com

Online published on 12 February, 2013.

Abstract

The study assessed the quality of different brand of diclofenac sodium sustained release tablet sourced from medical representative from different pharmaceutical manufacturer in India by evaluating their pharmaceutical and chemical equivalence. The organoleptic and physiochemical properties of these diclofenac sodium tablets were assessed according to established methods. The result of weight variation, swelling study, drug content and drug release of all marketed product comply with established limits. The diclofenac sodium tablet, A exhibited slowest time required to dissolved the 50% of the drug (7.42±0.143 minutes) and lowest value of swelling ratio (0.067±0.015) in 4 hour compared to other tablet. However, tablet showed highest drug content (98.38±0.343) compare to other tablets. Statistical assessment of various in-vitro parameters was also conducted to establish if there were any significance differences among them

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Keywords

Diclofenac sodium, drug content, dissolution, friability, weight variation.

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