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Research Journal of Pharmacy and Technology
Year : 2012, Volume : 5, Issue : 10
First page : ( 1293) Last page : ( 1296)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Quantitative Estimation of Dapoxetine Hydrochloride from Tablet Formulation by Colorimetric Methods Using Chlorophenol Red, Methyl Orange and Cosneasie Brilliant Blue R Dyes

Singhvi Indrajeet*, Prajapati Ashwin, Jain Vibhash

Pacific College of Pharmacy, Pacific Hill's, Air Port Road, Pratap Nagar Extn., Debari, Udaipur (Rajasthan)

*Corresponding Author E-mail: indrajeetsinghvi@yahoo.com

Online published on 12 February, 2013.

Abstract

Three simple and sensitive colorimetric methods have been developed for the quantitative estimation of Dapoxetine Hydrochloride (DPH) from Pharmaceutical tablet dosage form. Developed methods are based on the formation of chloroform extractable ion pair coloured complex of drug with Chlorophenol Red (CPR, Method A), Methyl Orange (MO, Method B) and Cosneasie Brilliant Blue R (CBB, Method C). The complex formed in method A, B and C showed maximum absorbance at 406.0 nm, 422.0 nm and 624.0 nm respectively. Linearity was obeyed in concentration range of 5–30 μgm/ml, 5–20 μgm/ml and 10–60 μgm/ml of DPH for method A, B and C respectively. The results of analysis were validated statistically and by recovery studies.

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Keywords

Dapoxetine Hydrochloride, Chlorophenol Red, Methyl Orange, Cosneasine Brilliant Blue R, Colorimetric method.

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