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Research Journal of Pharmacy and Technology
Year : 2011, Volume : 4, Issue : 9
First page : ( 1483) Last page : ( 1489)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

Antiyeast, Antioxidant and Anticancer Activity of Tribulus terrestris Linn and Bougainvillea spectabilis Linn

Kumar D. J. Mukesh1, K. Sonia2,*, R. Madhan3, K. Selvakumar3, P.T. Kalaichelvan1

1Centre for Advance Studies in Botany, University of Madras, Chennai, India

2Department of Biochemistry, Periyar University, Salem, India

3Department of Applied Biology and Nanobiosciences, BioLim Centre for Life Science, Chennai, India

*Corresponding Author E-mail: anbusonia@gmail.com

Abstract

Ethanolic extracts of leaves, fruits and stem of Tribulus terrestris and leaves of Bougainvillea spectabilis were prepared and assessed for anti-yeast activity on Candida albicans and Malassezia furfur at 50 μl and 100 μl concentrations, compared with Fluconazole anti-yeast agent. The antioxidant activity was examined by various methods such as DPPH, ferrous ion reducing antioxidant power, ferrous ion chelating ability assay and cerium (IV) ion reducing power assay and compared with ascorbic acid, α-tocopherol, rutin and quercitin. The extracts were also evaluated for anticancer activity such as decatenation assay and catalytic activity assay and compared with KDNA. It was observed that the fruit of T. terrestris and leaves of B. spectabilis has flavanoid and saponin compounds by Thin layer chromatography. From the results, it is evident that ethanolic extract of fruit of T. terrestris and leaves of B. spectabilis has maximum anti-yeast activity against candida albicans at 100 μl concentration and has a potent antioxidant and anticancer activity.

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Keywords

Tribulus terrestris Linn, Bougainvillea spectabilis Linn, Kinetoplast DNA, 1,2-diphenyl-2-picryl hydrazyl (DPPH), Thin Layer Chromatography.

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