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Research Journal of Pharmacy and Technology
Year : 2011, Volume : 4, Issue : 7
First page : ( 1147) Last page : ( 1150)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.

In-Vitro Alpha-Amylase Inhibition Action of Isolated Phytoconstituent in Zanthoxylum rhetsa (Roxb) Bark.

Pai Vasudev*, Savadi Rudraprabhu V., Bhandarkar Anant

Department of Pharmacognosy, KLE'S college of Pharmacy, Vidyanagar, Hubli (Karnataka) India

*Corresponding Author E-mail: pai_pharmacist@yahoo.co.in

Online published on 3 April, 2013.

Abstract

Medicinal plants have curative properties due to the presence of various complex chemical substance of different composition, which are found as secondary plant metabolites in one or more parts of these plants. In present study, in vitro α-amylase inhibition was used to evaluate hypoglycemic effects of various extracts of Zanthoxylum rhetsa (Roxb) bark revealed the presence of alkaloids, tannins, flavonoids, phenolic compounds, steroids. Further, chromatographic isolation of methanolic extract were carried out and direct chloroform extract is used. Isolate from methanolic extracts shown the presence of flavonoidal moiety and is confirmed by analytical techniques. It has shown significant percentage inhibition action +5.67 compared to control whereas chloroform extract has not shown alpha amylase enzyme inhibition.

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Keywords

α-amylase inhibition, antidiabetic, postprandial hyperglycemia, Zanthoxylum rhetsa Bark.

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