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RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY
Year : 2021, Volume : 14, Issue : 1
First page : ( 317) Last page : ( 320)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2021.00058.5

Serum levels of prostaglandin E2 (PGE2) and interleukin 17 (IL-17) are associated with Angiogenesis and Metastasis in breast cancer patients

Bilal Maram1*, Al-Saleh Jumana2, Fakher Faihaa Abo3

1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria.

2Assisstant Professor, Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria.

3Associate Professor, Department of Laboratory Medicine, Faculty of Medicine, Damascus University, Damascus, Syria.

*Corresponding Author E-mail: maramybilal86@gmail.com

Online published on 22 April, 2021.

Abstract

Background: The link between chronic inflammation and tumorogenesis has been noted for a long time. Breast tumor cell-derived prostaglandin E2 (PGE2) induces the production of interleukin 23 (IL-23) that enhances IL-17 secretion. Permanent release of these molecules leads to augmentation of their serum concentrations that may be used as novel clinical markers for diagnosis and prognosis. The aim of this research was to evaluate levels of IL-17 and PGE2 in blood serum of breast cancer patients, and to determine whether these levels correlate with the disease progression Material and Methods: Pre-operative serum samples were collected from 41 patients with breast cancer and 28 patients with benign breast tumors. IL-17 and PGE2 levels were measured using ELISA. Furthermore, correlations between levels of these molecules and clinicopathological parameters were determined. Results: We demonstrated that serum levels of PGE2, but not IL-17, were significantly increased in breast cancer patients as compared with benign tumor patients. Moreover, both IL-17 and PGE2 levels were increased in cancer patients with angiogenesis and lymph node metastasis. A positive correlation was also identified between IL-17 and PGE2 levels. Conclusion: The present study indicates that elevated IL-17 and PGE2 serum concentrations are associated with angiogenesis and metastasis of breast cancer. So, our data suggest that IL-17 and PGE2 could be developed as potential biomarkers of breast cancer diagnosis and prognosis, however more comprehensive results are needed.

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Keywords

Breast tumor, Prostaglandin E2, IL-17, Angiogenesis, Metastasis.

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