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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4172) Last page : ( 4174)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00736.2

An Insilico pharmacological evaluation of saraswatharishtam for alzheimer's disease - an ayurvedic formulation

Aparna TM, Merlin N.J.*, Dharan Shaiju S

Department of Pharmacology, Ezhuthachan College of Pharmaceutcial Sciences, Neyyantikara-695124, TVM

*Corresponding Author E-mail: merlinbinu76@yahoo.co.in

Online published on 16 September, 2020.

Abstract

Saraswatharishtam is a standard Ayurvedic tonic for treating mental disorders in general. The present study deals with the insilico ADME evaluation and molecular docking studies of phytoconstituents present in Saraswatharishtam using SWISS ADMET and docking software such as Pyrex, pyMOL and Open babel. The results of the study shows that Baccosides, Kaemferol, Puerarinand Gingerol shows better docking score and hydrogen bond interaction with its potential Nicotinic Acetylcholine Receptor(1HOY) which may be responsible for neuroprotective activity.

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Keywords

Saraswatharishtam, Swiss ADME, Molecular docking, BBB, Neuroprotective.

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