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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4125) Last page : ( 4129)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00728.3

Effect of vitamin d supplement on the risks of cardiovascular disease in patients with type 2 diabetes in the Kurdistan region of Iraq

Sofihussein Hasan Qader1, Al-Naqshabandi Abdulqader Azeez2, Sami Hawri Fatih3, Saeed Mudhafar Mohamed M.4,*

1Polytechnic University of Sulaimani, Technical Institute of Sulaimani, Department of Pharmacy, Sulaimani, Kudistan Region, Iraq

2Hawler Medical University, College of Pharmacy, Hawler, Kudistan Region, Iraq

3Cihan University, College of Science, Hawler, Kudistan Region, Iraq

4Polytechnic University of Sulaimani, Technical Institute of Sulaimani, Department of Pharmacy, Sulaimani, Kudistan Region, Iraq

*Corresponding Author's E-mail: mudhafar.pharm@gmail.com

Online published on 16 September, 2020.

Abstract

Bachground

Hypovitaminosis D has been observed in all ethnicities and age groups worldwide. Beyond its role in bone metabolism and calcium homeostasis, there is abundant evidence showing that there is a link between vitamin D and major pathological conditions such as cancer, type II diabetes mellitus, autoimmune disease, and various inflammatory disorders. Decreasing risks of these diseases involve the supplementation of vitamin D3 on daily doses at its normal level. This research focused on the role of vitamin D3 supplement on the level of glycated hemoglobin and hs-CRP and its impact on reducing risks of cardiovascular disease in type-2 diabetic vitamin D deficient patients.

Methods

The study sample consisted of 91 patients (17 males and 74 females). For a period of 14 weeks, they received daily supplementation with 5000 IU added to their other treatment regimens. Before and after supplementation with vitamin D3, data on the patients’ anthropometric characteristics were collected and analyzed. Body mass index was measured. Afterwards, fasting venous blood samples were taken from the patients for investigation of, HbA1c, FBS, lipid profile, fasting serum insulin (mU/L), amylin (pg/ml), C-peptide (ng/ml), TNF-a,IL6, and hs-CRP. TG/HDL-c, and the homeostasis model of assessments of insulin resistance (HOMA-IR) were calculated.

Results

The current study was carried out on 91 patients withtype-2 diabetes. Fourteen weeks of supplementation with vitamin D resulted in sharp amelioration in vitamin D level which in turn led to a significant decrease in the level of HbA1c, fasting blood glucose, IL-6, TNF-α, hs-CRP, waist circumference (WC), BMI, TG and TG/HDL-c ratio. While, a non-significant drop in HOMA-IR, Total cholesterol, and LDL-c. It also resulted in significant improvement in the level of fasting insulin, C-peptide, and HDL-c, and non-significant improvement in amylin.

Conclusion

Vitamin D supplementation significantly decreased percentage of glycated hemoglobin as well as the level of hs-CRP, which in turn results in reducing cardiovascular disease risks in type-2 diabetic vitamin D deficient patients.

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Keywords

Vitamin D, Cardiovascular disease, Diabetes mellitus.

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