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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4099) Last page : ( 4104)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00724.6

Formulation and evaluation of gastro retentive floating tablets of ritonavir

Sarmah Jahnabi*, Choudhury Ananta

Faculty of Pharmaceutical Sciences, Assam Down Town University, Guwahati-781026, India

*Corresponding Author E-mail: jahnabisarmah22@gmail.com

Online published on 16 September, 2020.

Abstract

Objective

The objective of this study was to formulate floating tablets (GRDDS) of Ritonavir using wet granulation technique to increase its bioavailability and the gastric residence time of the dosage form.

Methods

The Ritonavir tablets were prepared by wet granulation method. The tablets were prepared by using two different grades of polymers i.e; HPMC K 15M and HPMC K 4M which act as a release retardant polymer. Sodium bi carbonate (NaHCO3) was used as a gas degenerating agent and MCC (Micro crystalline cellulose) was used as a diluent. Solution of gelatin and ethyl cellulose was used as a binder in the preparation of formulation. The final mixing was done by adding talc and magnesium stearate to the granules. Then the prepared formulation were subjected to some evaluation parameters like hardness, friability, weight variation, drug content, buoyancy property, drug release study etc.

Results

In the FT-IR study it was revealed that there is no interaction between the drug and excipients. The formulation which containing the combination of HPMC K 15M polymer and Sodium bi carbonate shows good drug release pattern with less floating lag time and good floating duration.

Conclusion

The in vitro drug release pattern of Ritonavir floating tablets was fitted to different kinetic models which showed the highest regression for Higuchi order kinetics.

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Keywords

Ritonavir, Floating tablets, Gastric residence time, Bioavailability, Gastro retentive drug delivery systems.

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