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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 9
First page : ( 4041) Last page : ( 4046)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00714.3

Neuroprotective potency of Tamarindus indica seed extract for preventing memory impairment in rat model of alzheimer's disease

Muhammad Ihwan Narwanto1,2,*, Rahayu Masruroh3, Soeharto Setyawati4, Nurdiana4, Widodo Mochammad Aris4

1Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, Indonesia

2Department of Anatomy, Faculty of Medicine, University of Jember, Jember, Indonesia

3Department of Neurology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia

4Department of Pharmacology, Faculty of Medicine, University of Brawijaya, Malang, Indonesia

*Corresponding Author E-mail: muhammadnarwanto@unej.ac.id

Online published on 16 September, 2020.

Abstract

Objective

To investigate the neuroprotective potency of Tamarindus indica seed extract (TSE) for Alzheimer's prevention-based on the pathogenesis of the disease.

Methods

Rats were divided into 6 groups normal, control, aluminum chloride (AlCl3), low, moderate and high dose of TSE. The Morris water maze test was used to evaluate the memory. Proinflammatory cytokines levels were estimated by enzyme-linked immunosorbent assay method. Malondialdehyde levels were measured by the thiobarbituric acid reactive substances method.

Results

Administration of 50 mg/kg TSE were decreased cerebral cortex levels of proinflammatory cytokines and lipid oxidation products, and protected memory impairment due to the induction of AlCl3.

Conclusion

Data from this study confirmed the neuroprotective benefits of TSE for Alzheimer's prevention based on the pathogenesis of the disease. Further, these results could lead to the development of Alzheimer's prevention.

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Keywords

Morris water maze, Aluminum chloride, IL1β, TNFα, Malondialdehyde.

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