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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3887) Last page : ( 3892)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00688.5

Nanosponge based hydrogels of etodolac for topical delivery

John Deepika, Charyulu R. Narayana*, Ravi G. S., Jose Jobin

Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangaluru-575 018, Karnataka, India

*Corresponding Author E-mail: narayana@nitte.edu.in

Online published on 16 September, 2020.

Abstract

Topical drug delivery system refers to a formulation that carries drug substance into contact with or through the skin for the treatment of cutaneous disorders or the cutaneous manifestation of general diseases. Etodolac is a non-steroidal anti-inflammatory drug used for the treatment of postoperative pain and infections, rheumatoid arthritis and osteoarthritis. SMEDDS of etodolac was developed using oleic acid, tween 80, PEG 400 and evaluated for zeta potential and drug content which were found to be +39mV and 93.33% respectively for F2 formulation. The SMEDDS incorporated etodolac loaded nanosponge were prepared by emulsion solvent evaporation method and optimized using Design Expert® software. The optimized SMEDDS incorporated etodolac loaded nanosponge formulation was found to possess 106.3nm particle size, 0.320 PDI, 87.46% entrapment efficiency and rough, porous surface. Further, all the nanosponge based hydrogel formulations had 6.8 pH and F2 formulation was found to possess 598 cps viscosity, 5.5±0.01cm spreadability and 73.3±0.01% drug content. F4 formulation showed the highest percentage swelling of 93.45% within 24 h. The in vitro drug release and kinetics studies confirmed the sustained release of the drug from the formulation with diffusion controlled drug release mechanism. Hence the nanosponge based hydrogels of etodolac were found to be promising for topical delivery.

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Keywords

Topical, Etodolac, SMEDDS, Nanosponge, Hydrogels.

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