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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 8
First page : ( 3759) Last page : ( 3764)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00665.4

Formulation and evaluation of floating mucoadhesive microspheres loaded with antiulcer drug

Ali Alfiya1, Pillai Haritha H2,*, Mathew Preetha3, Beena P4, Das Christina5, Abraham Elessy6

1M Pharm, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera

2Final Year M Pharm, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera

3Assistant Professor, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera

4Professor, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera

5Assistant Professor, Department of Pharmaceutics, Nazareth College of Pharmacy, Othera

6Principal, Nazareth College of Pharmacy, Othera

*Corresponding Author E-mail: harithahpillai1997@gmail.com

Online published on 16 September, 2020.

Abstract

The objective of the present study was to formulate and evaluate Floating-mucoadhesive microspheres which is loaded with famotidine for the treatment of Helicobacter pyloric (H. pylori) infection. Formulation of Gastro - Retentive Dosage Forms (GRDFs) containing suitable drug candidate which would remain in stomach and/or upper part of GIT for prolonged period of time thereby is maximizing the drug release at desired site within the time before GRDFs leave the stomach and or upper part of GIT. Tablets were prepared by Ionic gelation method by using the polymers such as HPMC K4m, ethyl cellulose, sodium alginate, calcium chloride and by keeping the concentration of HPMC, sodium alginate, calcium chloride were constant and five formulation were prepared was evaluated for drug - excipient compatibility, density, buoyancy test, mucoadhesion force, percentage yield, entrapment efficiency, particle size and in-vitro release profile and stability studies of optimized formulation. Analysis of drug release from tablet indicates drug release by zero order rate kinetics. No significant change was observed in physical appearance, drug content, floatability or in vitro dissolution pattern after storage at 40°C±2°/75% RH for six months. Formulation no: 5 was found to be the optimized one which is satisfying all the required specifications.

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Keywords

Mucoadhesives, Famotidine, Floating, Microspheres, HPMC.

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