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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3409) Last page : ( 3413)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00606.X

The Role of Zinc Supplementation on the level of MDA and the number of Mycobacterium tuberculosis colonies in male tuberculosis Wistar rats

Sahadewa Sukma1,2,*, Sargowo Djanggan3, widodo Muhammad Aris4, Kusuma HMS Chandra5

1Doctoral Program of Medical Science, Medical Faculty, Universitas Brawijaya, Malang, East Java, Indonesia

2Department of Public Health, Medical Faculty, Universitas Wijaya Kusuma, Surabaya, East Java, Indonesia

3Cardiology and Vascular Medicine Department, Faculty of Medicine, Brawijaya University, Malang, Indonesia

4Department of Pharmacology, Faculty of Medicine, University Brawijaya, Malang, East Java, Indonesia

5Laboratory of Pediatris, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia

*Corresponding Author E-mail: sukmasahadewa1717@gmail.com

Online published on 10 August, 2020.

Abstract

Objective

To examine the role of zinc supplementation on the level of MDA and the number of Mycobacterium tuberculosis colonies in male tuberculosis Wistar rats

Methods

This is a pure experimental study (true experimental laboratory) which was carried out in a laboratory in vivo by using a post-test control group design with the subjects were male Wistar (Rattus norvegicus) rats aged 2–3 months, obtained from the PUSVETNA unit (Surabaya).

Results

Significant differences were found in levels of MDA and the number of Mycobacterium tuberculosis colonies in male tuberculosis male wistar rats compared with the control group.

Conclusion

This study found the ability of Zinc in reducing levels of oxidative stress in patients with tuberculosis and the function of Zinc in modulating the immune system. However in the actual clinical situation it is necessary to consider other comorbid conditions.

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