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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 7
First page : ( 3343) Last page : ( 3346)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00593.4

Creation of Cocoa butter bases for preparation of suppositories in pharmacy condition by the casting method

Chushenko V. M., Yarnykh T. G., Yuryeva G. B., Herasymova I. V.*

Technology of Drugs Department, National University of Pharmacy, 61002, Pushkinskaya St. 53, Kharkiv, Ukraine

*Corresponding Author E-mail: iryna_herasymova@ukr.net

Online published on 10 August, 2020.

Abstract

Purpose

The aim of the study is to create of cocoa butter bases for the preparation of suppositories in pharmacy condition with a various active pharmaceutical ingredients by casting method, which is hygienic, convenient, fast and efficient.

Methods

In the process, we used physical-chemical and pharmaco-technological methods of researches to study the basic properties of suppositories.

Results

The conditions for the creation of cocoa butter bases with various emulsifiers for the manufacture of suppositories in pharmacy condition by the casting method have been studied. The ratio between the cocoa butter and emulsifiers at which it is possible to prepare suppository bases has been established.

Conclusions

Based on the conducted research a cocoa butter bases with emulsifiers have been developed. Suppositories prepared by casting method were compatible with the requirements to suppository bases of the State Pharmacopoeia of Ukraine 2.0.

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Keywords

Suppositories, Technology, Suppository base, Cocoa butter, Pharmacy.

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