Structural, Spectral and Thermal studies of new bidentate Schiff base ligand type (NO) derived from Mebendazol and 4-Aminoantipyrine and it's metal complexes and evaluation of their biological activity
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A new Schiff base, methyl (E)-(6-(((1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4yl)imino)(phenyl)methyl)-1H-benzo[d]imidazol-2-yl)carbamate(L) has been synthesized from 4-aminoantipyrine and mebendazol. Metal complexes of the Schiff base were prepared from metal ions of MII = VO, Mn, Co, Ni, Cu, Zn, Cd and Hg in alcoholic medium with mole ratio (M:L) (1:2). The complexes have general composition [M(L)2Cl2].H2O, [(VO)(L)2(SO4)].H2O, [M(L)2(H2O)Cl].H2O, [Ni(L)2Cl].H2O. The ligand and all complexes were characterized by modern spectroscopic (FT-IR, UV_Vis,1HNMR,13CNMR, Mass spectroscopy, atomic absorption), along with elemental microanalysis, magnetic susceptibility measurements, thermal analyses, chloride content and molar conductance. In addition to evaluated their biological activity against two type of bacterial and one type fungus.
Schiff base, 4-Aminoantipyrine, Mebendazol, Metal complexes, Biological activity.