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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2859) Last page : ( 2863)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00509.0

A new stability indicating RP-UFLC method for determination of Luliconazole in bulk and pharmaceutical formulation

Bhanu Palyam, Sundararajan Raja*, Prathyusha Peethala, Mukthinuthalapati Mathrusri Annapurna

Department of Pharmaceutical Analysis, Gandhi Institute of Technology and Management, GITAM Institute of Pharmacy, Visakhapatnam, Andhra Pradesh-530045, India

*Corresponding Author E-mail: sraja61@gmail.com

Online published on 4 July, 2020.

Abstract

Luliconazole is a novel imidazole antifungal used in treatment of interdigital tinea pedis, tinea cruris, and tinea corporis. A simple, precise new ultrafast liquid chromatographic method has been developed and validated for the Luliconazole in bulk and pharmaceutical dosage form. Shimadzu ModelCBM-20A/20 Alite HPLC system equipped with PDA detector was used. The chromatographic separation was achieved using Phenomenex Gemini C18 column (150 mm × 4.60 mm i.d. 5μm particle size) with mobile phases containing Phosphate buffer (pH -4): Acetonitrile (60:40 v/v). The flow rate was maintained at 0.8ml/min. The detection was done at 299 nm. The retention time was found to be 6.378min. Luliconazole showed linearity in the concentration range of 5100μg/mL with linear regression equation y = 81537x + 6325.6 (R2 = 0.9999). The % RSD for precision and accuracy was found to be less than 2%.The LOD and LOQ were found to be 0.16 and 0.49.The proposed method was found to be simple, precise, accurate and validated according to ICH guidelines.

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Keywords

Anti -fungal, Luliconazole, ICH guidelines.

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