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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2843) Last page : ( 2848)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00506.5

Chicken intestine inflammation model for predictive in vitro screening of Anti-inflammatory activity

Jijith U. S.1,2, Jayakumari S.1,*

1School of Pharmaceutical Sciences, Vels Institute of Sciences, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, India

2College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode-673008, Kerala, India

*Corresponding Author E-mail: nisajayaa@gmail.com

Online published on 4 July, 2020.

Abstract

Objective

A key goal in pharmacological screening is a good understanding of the in vivo performance. So development of in vitro evaluations that could be correlated to in vivo performance would be commendable. The purpose of this research was to develop easily predictable in vitro method for the evaluation of antiinflammatory activity. Further, this research work was also aimed to establish an in vitro -in vivo correlation of anti-inflammatory activity.

Methods

Kappa-carrageenan was used to induce inflammation on the chicken intestine. We proposed a new apparatus which we name ‘Jijith-Jayakumari apparatus’ for the in vitro evaluation of anti-inflammatory agents. Diclofenac sodium was used as the model drug.

Results and Conclusion

The developed in vitro method using chicken intestine was worth for screening ant-inflammatory activities. A good correlation was obtained between in vitro and in vivo data. Thus, an IVIVC was established for antiinflammatory activity.

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Keywords

Jijith-Jayakumari apparatus, Kappa-Carrageenan, Diclofenac sodium, Chicken intestine.

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