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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2787) Last page : ( 2791)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00495.3

Formulation and Evaluation of Nano-fiber-based Transdermal patch of Cephalexin

Choudhary Sidra1, Dharashivkar Sanket1, Mahajan Chetan2, Gaikwad Madhuri3

1Department of Pharmaceutics, Dr. L. H Hiranandani College of Pharmacy, Ulhasnagar

2Scientist-B, Wool Research Association, Thane

3Department of Pharmaceutics, AIKTC School of Pharmacy, Panvel

*Corresponding Author E-mail: sidraeram@gmail.com

Online published on 4 July, 2020.

Abstract

In the present work polymeric nano-fiber patches were developed for the effective treatment of skin infection using cephalexin as model drugs. The nano-fibers were prepared by electro spinning technique by using polyvinyl alcohol (PVA) as a polymer and fibers were characterized on the basis of entrapment efficiency, fiber diameter, morphology, x-ray diffraction analysis, drug release behavior and in vitro antimicrobial test. The entrapment efficiency of the optimized formulation was 95%. The % cumulative release of drug from nano-fiber patch across the dialysis membrane was 96% at the end of 24h. The ex-vivo release of drug through nano-fiber patch across the goat skin was 81% at the end of 24 h.

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Keywords

Cephalexin, Nanofiber, Electrospinning.

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