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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2759) Last page : ( 2763)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00490.4

Phytochemical analysis, Antioxidant and Antiarthritic activities of different solvent extract of Aegle marmelos L. unripe fruit

Sivakumar G1, Gopalasatheeskumar K2,*, Gowtham K1, Sindhu E1, Raj K Akash1, Rajaguru B1, Sriram K2, Kalaichelvan V K2

1Department of Pharmacology, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India (Affiliated to Tamil Nadu Dr. M.G.R. Medical University)

2Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India

*Corresponding Author E-mail: gskpungai@gmail.com

Online published on 4 July, 2020.

Abstract

Arthritis is one of the foremost health troubles worldwide, leading causes of disability in western and developing countries. Therapies developed along the principles of western medicine are often limited in efficacy, carry the risk of adverse effects, and are often too costly, especially for the developing world. Aegle marmelos (L.) Correa (AM) commonly known as Beal or Bilva belonging to the family Rutaceae has been widely used in indigenous systems of Indian medicine due to its various medicinal properties. The secondary metabolites (phytochemicals) present in medicinal plants relation for their therapeutic value. For example, triterpenoids, flavonoids and related polyphenols have antiarthritic properties. But since there is no report on antiarthritic activity of unriped fruit extract of AM. Therefore aim of the current study is to evaluate the antiarthritic activity of AM. Phytochemical analysis of different extracts of AM revealed the presence of various bioactive phytochemical compounds was found in aqueous, methanolic, ethylacetate, chloroform and petroleum ether extracts of AM. In vitro antiarthritic activity of different extracts of AM was screened against protein denaturation against bovine serum albumin and egg albumin. The fruit extract of AM showed significantly higher anti-arthritic activity at increasing concentration. The flavonoids and triterpenoids present in AM may be the reason for this anti-arthritic activity. Hence, AM can be used as an anti-arthritic agent. The investigation is based on the need for anti-inflammatory/antiarthritic agents from natural sources with potent activity and lesser side effects as substitutes for chemical therapeutics. In future it would be important to understand molecular mechanism of Aegle marmelos.

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Keywords

Anti-inflammatory, BSA denaturation, Egg albumin, Flavonoids, Beal, Diclofenac sodium.

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