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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2715) Last page : ( 2719)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00483.7

Spectroscopic Estimation of Dapoxetine HCl using Multivariate Analysis

Krishnakumar P1, Sundarrajan T1, Kathiravan M K2, Manikandan K3,*

1Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram – 603203

2209, Dr APJ Abdul Kalam Research Lab, Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram – 603203

3Department of Pharmaceutical Analysis, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Kancheepuram – 603203

*Corresponding Author E-mail: gurumani12@gmail.com

Online published on 4 July, 2020.

Abstract

A sensitive and exact UV spectroscopic technique with a multilinear regression technique for assurance for Dapoxetine HCL in the drug dosage form. This technique relies upon the utilization of the linear regression equations by utilizing the interconnection between absorbance and concentration at five selected wavelengths. The outcomes were dealt with numerically and were found highly precise, reproducible and accurate. This technique is precise, linear and accurate between the limits of 10–50μg/mL. The excipients do not have any conflicts. The numerical analysis with the multilinear regression method was utilized. The information procured for the evaluation of Dapoxetine HCL in bulk drug dosage form evidenced the high-level accuracy and precision after the multivariate analytical technique. Subsequently, this technique is extremely valuable with uncomplicated mathematical contents, is more dependable than the other spectroscopic techniques then it suggests an application in calibration models for routine analysis. It has been validated and developed for further studies and quantification of Dapoxetine HCL in Bulk and pharmaceutical formulation.

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Keywords

Dapoxetine Hcl, Multivariate calibration technique, Pharmaceutical formulations, ICH guidelines, Validation.

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