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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 6
First page : ( 2629) Last page : ( 2633)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00467.9

Preparation and Evaluation of Mouth Dissolving Tablets of Loratadine by Direct Compression Method

Swamivelmanickam M.1,*, Venkatesan P.1, Sangeetha G.2

1Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India

2Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore, Karnataka, India

*Corresponding Author E-mail: swamivel@yahoo.com

Online published on 4 July, 2020.

Abstract

Loratadine, histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Administration of Loratadine through oral route is a challenge in children, who have difficulty to swallow tablets. In the present study, nine batches of Loratadine Mouth Dissolving tablets (MDTs) dosage form at the dose of 10 mg were formulated and evaluated. Results showed that thickness, weight variation, friability, hardness, and content uniformity of all five formulations were within the acceptable limits. But in the in-vitro dissolution study, formulation 7, 8 and 9 demonstrated better cumulative drug release than formulation 3 and 6. However, cumulative drug release of formulation 9 was comparable with innovator than formulation 3 and 6. Three month stability study of formulation 9 revealed that there were no significant change in physical parameters, drug content and dissolution profile. Hence the study concludes that Loratadine mouth dissolving tablets formulated using starch-1500 and microcrystalline cellulose (Formulation 9) showed better characteristics of mouth dissolving tablets.

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Keywords

Loratadine, Mouth dissolving tablets, microcrystalline cellulose and guar gum.

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