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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2516) Last page : ( 2521)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00448.5

Self Nano Emulsifying Drug Delivery System: A Novel Technique for Enhancement of Oral Bioavailability

Arun Jagdish Kumar1, Rajeshwar V1,*, Shrivastava Birendra1, Bakshi Vasudha2

1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan-302017, India

2School of Pharmacy, Anurag Group of Institutions, Venkatapur (V), Ghatkesar (M), Medchal (Dist), Hyderabad, Telangana-500038

*Corresponding Author E-mail: rajeshwar.vodeti@gmail.com

Online published on 16 June, 2020.

Abstract

There has been a resurgence of interest in nano emulsions for diverse pharmaceutical applications considering the fact that low-power emulsification techniques, including spontaneous or self-nano emulsification, have been defined. Self-nano emulsifying drug delivery structures (SNEDDS) are anhydrous homogenous liquid mixtures along with oil, surfactant, drug and co-emulsifier or solubilizer, which spontaneously form oil-in-water nanoemulsion of about 200 nm or less in size upon dilution with water below gentle stirring. The physicochemical properties, drug solubilization ability and physiological targets notably govern the selection of the SNEDDS additives. The composition of the SNEDDS can be optimized with the help of Phase diagrams, whereas statistical experimental design can be used to further optimize SNEDDS. it can improve oral bioavailability of various hydrophobic drugs Cellular uptake is enhanced due to nanosized droplets of SNEDDS.

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Keywords

SNEEDS, Phase diagram, Co-Surfactant, Bioavailability, Nanoemulsion.

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