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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2439) Last page : ( 2444)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00437.0

Incision Wound healing, Anti-inflammatory and Analgesic activity of Amaranthus spinosus in Wistar rats

Paswan Shravan Kumar1,2, Srivastava Sajal2,*, Rao Chandana Venkateswara1

1Pharmacology Division, CSIR-National Botanical Research Institute, Lucknow-226001, Uttar Pradesh, India

2Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Gomati Nagar, Lucknow-226010, Uttar Pradesh, India

*Corresponding Author E-mail: ssrivastava2@lko.amity.edu

Online published on 16 June, 2020.

Abstract

The Aim of the present study to assess the Amaranthus spinonous in case of Incision wound model Anti-inflammatory and Analgesic activity (Hot plate, Tail flick method). The whole plant extraction was performed using 65% ethanol followed by phytochemical screening to determine secondary metabolites present in the plant. Wound healing activity of A. spinosus was determined using wound incision mode on rats. Animals were treated with two concentrations (5% and 10% w/w ointment) of A. spinosus and soframycin was used as standard and the study of analgesic and anti-inflammatory activity distributed in six different concentrations and observed different time period with the help of Plethysmometer at 0hr, 1hr, 2hr, 3hr, 4hr and 5hr after the administration of carrageenan to each group and Eddy Hot plate and Tail flick apparatus, the observation made at 0, 30, 60 and 90 min after oral administration of the samples. The evaluated the effect of 65% ethonolic extract of Amaranthus spinosus on incision wound, anti-inflammatory and analgesic activity. It has been observed that the ethonolic extract shown the maximum percentage protection toward inflammation comparison to other extract. The plant ASE prevents and reduces the development of inflammationin animals in carrageenan, hot plate and tail flick method. It can be concluded from the study that Amaranthus spinosus possess significant wound healing property and potential sources to treat inflammation.

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Keywords

Amaranthus spinosus, Incision Wound model, Carrageenan, Analgesic Activity, Acute dermal toxicity.

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