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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2387) Last page : ( 2392)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00429.1

Synthesis of Citosan Nanocarrier Systems for Improving SSRI-Fluoxetine Efficacy in MDD

Dixit Noopur1,*, Trivedi Aditya2,**, Ahirwar Dheeraj1

1Department of Pharmaceutical Sciences, SOP CEC, India

2Department of Pharmaceutical Sciences, SIP, India

*Corresponding Author E-mail: noopurtrivedi11@rediffmail.com

**aditrivedi99@yahoo.com

Online published on 16 June, 2020.

Abstract

The privilege of delivering the Fluoxetine (SSRI) drug intra nasaly through citosan Nanocarrier Systems in order to enhance the drug efficacy in terms of dose, frequency and patient compliance over its oral dosage form. These nanocarrier was Synthesis and were evaluated by studying their drug loading and entrapment efficiency, in vitro release and characterization including particle size and morphology, pH range and viscosity measurements. Nanocarrier Systems possessed optimum droplet size, polydispersity and viscosity with a promising release and permeation properties and characterized by their patient friendly nonirritant property due to their compatible pH values with human tissue. Such results shed a beam of light on the opportunity of the nasal delivery of Synthesised citosan Nanocarrier Systems in providing a more sustainable controlled delivery of the drug for longer periods, over two weeks, in contrast to the oral dosage form, citosan Nanocarrier Systemhelped in limiting the inconvenient drawbacks accompanied with the oral dosage form.

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Keywords

Nanoparticles, chitosan, Fluoxetine, Nanocarrier, SSRI.

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