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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2373) Last page : ( 2375)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00426.6

An Apparatus for the determination of rat paw Edema during In vivo Evaluation of Anti-inflammatory agents

Jijith U. S.1,2, Jayakumari S.1,*

1School of Pharmaceutical Sciences, Vels Institute of Sciences, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-600117, India

2College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode-673008, Kerala, India

*Corresponding Author E-mail: nisajayaa@gmail.com

Online published on 16 June, 2020.

Abstract

In vivo evaluation of anti-inflammatory agents normally involves the measurement of rat paw volume. Some notable equipment for in vivo measurement of rat paw volume includes plethysmometer, screw gauge and vernier calipers. Balance method is also reported for the purpose. The present study describes development and validation of a simple apparatus for the determination of rat paw volume suitable for in vivo evaluation of anti-inflammatory agents. The calibration plot obtained with the developed apparatus was linear with a high R2 value of 0.983. Thus it was confirmed that the apparatus is useful for the determination of rat paw volume.

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Keywords

Paw edema, plethysmometer, screw gauge, vernier calipers, balance method.

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