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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2329) Last page : ( 2334)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00419.9

The Effect of Metformin on Mean Platelet Volume

Dib Sherin1,*, Makhous Rana2

1Master Student in Pharmacology and Toxicology Department Faculty of Pharmacy, Tishreen University. Lattakia, Syria

2Doctor in Pharmacology and Toxicology Department Faculty of Pharmacy, Tishreen University, Lattakia, Syria, Rana.makhous@tishreen.edu.sy

*Corresponding Author E-mail: sherindib@gmail.com

Online published on 16 June, 2020.

Abstract

Background and objective

Diabetes mellitus (DM) is a global pandemic. The increased Mean platelet volume (MPV) and its activity may play a role in the development of vascular complications of this metabolic disorder. Metformin, the first-line therapy for T2DM, the only drug demonstrated to reduce cardiovascular complications in diabetic patients. However, whether metformin can effectively prevent thrombosis and its potential mechanism of action is not fully understood. In this study, the first aim is to determine whether there is a difference in MPV between diabetics with and without macro-and microvascular complications, compared to nondiabetics. The second aim is to examine the effects of metformine on MPV values in newly diagnosed type 2 DM patients on metformin monotherapy, and to investigate whether a correlation exists between MPV and fasting blood glucose changes after and before treatment.

Methods

MPV values were measured MPV in 87 newly diagnosed Type 2 diabetic patients, 25 insulin-dependent diabetic patients and 40 nondiabetic control subjects, who had complete blood count on venous blood sample taken into tripotassium EDTA, using automatic blood counter (Diagon D-Cell 60 CBC Eurup). The blood glucose level was measured by glucose oxidase method. Statistical evaluation was performed by SPSS for Windows statistics programme using linear regression analysis, Student's t, one way Anova, and Pearson correlation tests.

Results

MPV values were significantly higher in Insulin-dependent T2DM group compared to the newly diagnosed T2DM and control [9.7 ± 0.78 FL vs 8.52 ± 0.8 FL and 8.48 ± 0.9 FL (P=0)], respectively. Among the newly diagnosed patients MPV values showed a low positive correlation with patient age (R = 0.37, P= 0) but no correlation was with BMI (R=-0.001 ، P=0.99) and initial fasting plasma glucose (P= 0.111, R=0.172). MPV values were significantly reduced after 6-month metformin therapy [8.56±0.78 vs 8.18±0.70 (P<0.05)]. There were no statistically significant associations of ΔMPV with ΔFBG levels (beta coefficient=0.41, P=0.51) after metformin treatment

Conclusions

Our results showed that MPV values significantly higher in insulin-dependent T2DM patients than in the newly diagnosed T2DM patients and nondiabetic controls. The increased MPV may be due to the diabetic complication which increase with disease progression. Our results suggest that metformin had decreased MPV in diabetes mellitus Regardless of glucose lowering effect. These findings may provide a further explanation for the anti-atherogenic effect of metformin.

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Keywords

Metformin, Mean Platelet Volume, Diabetes Mellitus, Vascular Complications, Atherosclerosis.

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