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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2261) Last page : ( 2265)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00407.2

Biological Active Fluorobenzoates of Piperidine Range

Maksatova A. M.1, Akhmetova G. S.2, Datkhayev U. M.1, Omyrzakov M. T.3, Praliyev K. D.2, Ross S. A.4, Seilkhanov T. M.5, Seilkhanov O. T.5

1Asfendiyarov Kazakh National Medical University, 050000, Almaty, Kazakhstan

2Institute of Chemical Sciences named after A.B. Bekturov, 050010, Almaty, Kazakhstan

3GxP Company LLP, 050059, Almaty, Kazakhstan

4University of Mississippi, 38677, Missisipi, USA

5Sh. Ualikhanov Kokshetau State University, 202000, Kokshetau, Kazakhstan

Corresponding Author E-mail: gulgakhmet@mail.ru

Online published on 16 June, 2020.

Abstract

P-fluorine, m-fluorine, o-fluorinebenzoates of 1-propyl-4-hydroxypiperidine and 1-benzyl-4-hydroxypiperidine p-fluorobenzoate have been synthesized, which showed local anesthetic activity of varying degrees. Fluorobenzoic esters of secondary alcohols cause deep and prolonged anesthesia, the introduction of fluorine leads to local anesthetics with varying degrees of effectiveness.

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Keywords

P-fluorine, m-fluorine, o-fluoro-benzoylcarbonyl chloride, N-propylpiperidin-4-one, N-benzylpiperidin-4-one, esters, local anesthetic activity.

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