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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2241) Last page : ( 2245)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00403.5

Formulation and Evaluation of Sustained Release Colon Targeted Mesalamine Tablet

Kadam Sagar D.1,*, Dhole Shashikant2, Chitlange Sohan1

1Derpartment of Pharmaceutics, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, 411018

2Derpartment of Pharmaceutics, PES Modern College of Pharmacy, Moshi, Pune

*Corresponding Author E-mail: sagarkadam1111@gmail.com

Online published on 16 June, 2020.

Abstract

For the treatment of a range of local diseases such as ulcerative colitis, Crohn's disease, irritable bowel syndrome, chronic pancreatitis, and colonic cancer Colon-specific drug delivery systems (CDDS) are used. In addition, the colon can be a potential site for the systemic absorption of several drugs to treat non-colonic conditions. Colon targeted drug delivery system of Mesalamine tablets were prepared by using different formulae by direct compression method by using different concentration of Hydroxypropyl methyl cellulose (HPMC) and Ethyl Cellulose (EC). All the formulations of tablet (F1 to F6) were subjected for in vitro dissolution in 0.1 N HCL (pH 1.2) for suitability for colon specific drug delivery system. Tablets were evaluated for micrometric properties of granules, physical properties and drug content. F5 was optimized and subjected to coating based on evaluation results. The dissolution study of F5 revealed in simulated intestinal fluid release was 85.52% at the end of 6 h and was 101% at the end of 8 h. the studies confirmed that the designed formulation could be used potentially for colon delivery by controlling drug release in intestine.

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Keywords

Mesalamine, Diffusion, Inflammatory bowel disease, colon targeted, Hydroxypropyl methyl cellulose.

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