Design and Development of Novel 1, 3-Thiazin-4-one compounds derived from Pyrazine-2, 3-Dicarboxylic Acid: Synthesis and Bioactivity Screening
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In this study, a variety of new 1, 3-thiazin-4-one compounds bearing 1, 3, 4-thiadiazoles and/or 1, 2, 4-triazoles moieties have been prepared via their relating Schiff bases with good yields by intramolecular cyclocondensation reaction starting with pyrazine-2, 3-dicarboxylic acid. The structures conformity of newly synthesized compounds were based on their physiochemical properties, elemental analysis, as well as FTIR, 1H NMR, and 13C NMR spectra. These newly compounds have been screened for their antimicrobial activities with excellent results.
Bioactivity screening, 1, 3-Thiazin-4-one, Pyrazine-2, 3-dicarboxylic acid, Schiff bases, Six-membered ring, β-Mercaptopropionic acid.