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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2221) Last page : ( 2227)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00399.6

Design and Development of Novel 1, 3-Thiazin-4-one compounds derived from Pyrazine-2, 3-Dicarboxylic Acid: Synthesis and Bioactivity Screening

Ayyash Ahmed N.1,*, Habeeb Hadeel Q. Abdalrazzaq2, Fadel Entesar J.1

1Lecturer of Organic Chemistry, Ph. D. of Heterocyclic Chemistry, Department of Applied Chemistry, College of Applied Sciences, University of Fallujah, Anbar, Iraq

2Assist. Lecturer of Organic Chemistry, M. Sc. of Organic Chemistry, Department of Nursing, Alfarabi University College, Baghdad, Iraq

*Corresponding Author E-mail: ayyash1982@gmail.com

Online published on 16 June, 2020.

Abstract

In this study, a variety of new 1, 3-thiazin-4-one compounds bearing 1, 3, 4-thiadiazoles and/or 1, 2, 4-triazoles moieties have been prepared via their relating Schiff bases with good yields by intramolecular cyclocondensation reaction starting with pyrazine-2, 3-dicarboxylic acid. The structures conformity of newly synthesized compounds were based on their physiochemical properties, elemental analysis, as well as FTIR, 1H NMR, and 13C NMR spectra. These newly compounds have been screened for their antimicrobial activities with excellent results.

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Keywords

Bioactivity screening, 1, 3-Thiazin-4-one, Pyrazine-2, 3-dicarboxylic acid, Schiff bases, Six-membered ring, β-Mercaptopropionic acid.

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