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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2163) Last page : ( 2166)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00389.3

Method Development and Validation for the Analysis of Perindopril Erbumine and Amlodipine Besylate by RP-HPLC in Pure and Pharmaceutical Dosage Form

Badar Humera1, Dr. Yasmeen Ruheena2, Ayeen Fathima Qurratul1, Badar Juveria3

1Assistant Professor, Department of Pharmaceutical Analysis and Quality Assurance, Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, India

2Assistant Professor, Department of Pharm. D (Pharmacy Practice), Nizam Institute of Pharmacy, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Yadadri Bhuvanagiri (Dist)-508284, Telangana, India

3Student, St. Pauls College of Pharmacy, Sy. No.603 and 605, Nagarjuna Sagar Road, Turkayamjal, Hyderabad, Telangana, 501510

Corresponding Author E-mail: sanakhan020711@gmail.com

Online published on 16 June, 2020.

Abstract

The aim of the current manuscript is to develop and validate RP-HPLC method for the determination of perindopril erbumine and amlodipine besilate dosage form and to develop and validate calibration curve method and derivative method for the determination of perindopril erbumine and amlodipine besilate in bulk and tablet dosage forms. To develop a simple, rapid and specific RP-HPLC method for the estimation of perindopril erbumine and amlodipine besilate in bulk and combined pharmaceutical dosage forms. To develop a simple, rapid, accurate eco friendly less cost methods for the determination of perindopril erbumine and amlodipine besilate in bulk and tablet dosage forms. To validate the proposed methods in accordance with the analytical parameters mentioned in the ICH guidelines, such as system suitability, accuracy, precision, specificity, linearity, robustness.

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Keywords

Perindopril erbumine, Amlodipine besilate, Validation, Method development, ICH guidelines.

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