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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2155) Last page : ( 2158)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00387.X

Cytotoxic and Antiradical Activities of Extracts of Rhizopora apiculata (L)

Vijayakumar B.1,*, Banurekha J.2, Swarnalatha G.3, Jothieswari D.4

1Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Koudunthirapully, Palakkad, Kerala-678004, India

2Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Mission's Research Foundation (Deemed to be University), Salem-636308, Tamil Nadu, India

3Department of Pharmaceutical Chemistry, Mahathi college of Pharmacy, C.T.M, Angalu-CTM Road, Madanapalle, Andhra Pradesh-517325

4Department of Pharmaceutical Ananlysis, Sri Venkateswara College of Pharmacy, RVS Nagar, Chittoor, Andhra Pradesh-517127, India

*Corresponding Author E-mail: vijaykumarbvk86@gmail.com

Online published on 16 June, 2020.

Abstract

The petroleum ether and methanol crude extracts of Rhizopora apiculata (L) (Rhizoporaceae) were screened for cytotoxicity by MTT bioassay and antioxidant activity using three different methods. The active constituents of the plant Rhizopora apiculata (L) were extracted using petroleum ether and methanol. Both extracts were tested for cytotoxicity by MTT assay at a concentration range of 18.75, 37.5, 100, 150 and 300μg/ml. The percentage cell viability shown in Pet ether extract for human cervical adenocarcinoma cell lines (HeLa), human osteosarcoma cell lines (MG 63) and Breast adenocarcinoma (MC 67) were in the range of 102-91%, 100-84% and 101-78% respectively shows that pet ether extract does not have considerable cytotoxic activity. On the other hand, Petroleum ether and methanol crude extracts of Rhizopora apiculata (L) showed mild antioxidant activity with compared to ascorbic acid.

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Keywords

Rhizopora apiculata, Breast adenocarcinoma, Human osteosarcoma cell lines Ascorbic acid.

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