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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2107) Last page : ( 2111)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00379.0

Synthesis, Characterization and Evaluation of Ulcerogenic potential for NSAIDs-Alendronate based prodrug

Srivastava Ashish1,*, Mishra Ashutosh2, Rai A. K.1

1Department of Medicinal Chemistry, Institute of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, Uttar Pradesh, India

2Acharya Narendra Dev College of Pharmacy, Babhnan, Gonda-271313, Uttar Pradesh, India

*Corresponding Author E-mail: srivastava457@gmail.com

Online published on 16 June, 2020.

Abstract

Objective

Synthesis and Evaluation of Ulcerogenic potential for NSAID-Alendronate based prodrug.

Methods

Three NSAIDs (Diclofenac, Indomethacin and Ibuprofen) were conjugated with Alendronate though amide linkage. The synthesized prodrugs were evaluated for their ulcerogenic potential on wistar rats at the dose of 25, 50 and 100mg/kg.

Results

The severity index for the group administered with the parent drugs was in the range of ∼ 1–2.7. However, the severity index for the group administered with the prodrug was in the range of ∼0.5 to 1.8.

Conclusion

The newly reported prodrugs showed significantly less signs of ulcerogencity.

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Keywords

NSAID, Bisphosphonate, Prodrug, Ulcer, Combination.

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