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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2096) Last page : ( 2100)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00377.7

Lipid based solid dispersions of Olmesartan medoxomil with Improved oral Bioavailability: In vitro and ex Vivo Evaluation

Chopra Dhiraj Kumar*, Kar Durga Madhab, Sahu Pratap Kumar

School of Pharmaceutical Sciences, Siksha ‘O ’Anusandhan (Deemed to be University), Kalinga Nagar, Ghatikia, Bhubaneswar-751003, Orissa

*Corresponding Author E-mail: dhirajchopraphd@gmail.com

Online published on 16 June, 2020.

Abstract

The main aim of the current research work is to evaluate the potential of lipid based solid dispersions (OSD) to enhance oral bioavailability of Olmesartan Medoxomil (BCS Class II molecule). OSD have been prepared using different hydrophilic lipid based carriers such as gelucire 44/14 and gelucire 50/13 at the ratio of 1: 1, 1: 2 and 1: 3. Pearlitol SD 200 was used as hydrophilic carrier in all the formulations to convert the lipid based solid dispersion to free flowing powder. Solid dispersions were prepared by solvent evaporation method. Prepared OSD's were evaluated for their micromeritics properties, saturation solubility, in vitro dissolution and ex vivo permeability. Among the formulations prepared, formulation (OSD3) containing gelucire 44/14 (1: 3), Pearlitol SD 200 as carrier has shown enhanced drug release (70.2 ± 6.5 release in 30 minutes) and solubility (44.32mg/mL) compared to other formulations. Hence, this formulation is evaluated for comparative ex vivo permeability with pure drug and marketed formulation (Olmezest). It was found that the permeability of OSD3 was increased compared to pure drug and compared to marketed formulation. Hence, the study demonstrated that lipid based solid dispersion technology can lead to improve the bioavailability of poorly soluble drugs like olmesartan medoxomil significantly.

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Keywords

Lipid based, Liquid solid dispersions, Bioavailability, Dissolution, Solubility.

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