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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 5
First page : ( 2069) Last page : ( 2075)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00372.8

Preclinical Evaluation of Antihypertensive Activity of Combination of Herbs Extract in Wistar Rats

Satone Bhavika D., Deshmukh Atul A.*, Undale Vaishali R.

Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-411018, (M.S), India

*Corresponding Author E-mail: prof.adeshmukh@gmail.com

Online published on 16 June, 2020.

Abstract

Hypertension is the most common cardiovascular disease and is a major public health issue in developed as well as developing countries. In hypertension systolic blood pressure (SBP) rises above of 140 mmHg while diastolic blood pressure (DBP) is above of 90 mmHg. Hypertension is one of the leading cause of global burden of disease. It is one of the major cause of cardiovascular mortality, which is estimated to be 1.5 million deaths per year in India. The currently available antihypertensive drugs are not so efficient. Many ayurvedic herbs have shown antihypertensive activity. Brassica oleracea and Apium graveolens are two drugs that act on different pathophysiological mechanisms of hypertension. Hence the aim of this study was to evaluate the synergistic potential of the combination in hypertension. Antihypertension activity of combination with doses (100, 200, 400 mg/kg) was carried out with two i.e. 2K1C model and fructose induced hypertension. Biochemical estimations of Triglycerides, LDL, HDL, and Creatinine were carried out along with cardiac parameters like SBP, DBP, And Mean Blood Pressure. The results indicated dose dependent antihypertensive action of combination of drug. The antihypertensive action of combinations was found to be significantly greater than that of individual drugs thereby justifying the synergistic effect of the two drugs.

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Keywords

Hypertension, Brassica oleraceaApium graveolens, 2KC, DBP, SBP.

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