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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1967) Last page : ( 1971)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00354.6

Nanotechnology in Parkinson's Disease - A Review

Acharya Soumi, Meenambiga S. S.*

Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai-600117, Tamilnadu, India

*Corresponding Author E-mail: meenambiga.se@velsuniv.ac.in

Online published on 30 April, 2020.

Abstract

Parkinson's Disease is considered as a neurodegenerative disorder and is identified by the deterioration of the motor functions due to loss of the dopamine releasing neurons. Due to this dementia occurs which is characterised by forgetfulness and impairment in cognitive abilities. The effectiveness, cellular penetration and transport of drugs to the target organs, tissues or cells is the main hindrance in the diagnosis and the treatment of this disorder. The main obstacle in the drug delivery system is the presence of blood brain barrier which checks the penetration of drugs and causes side effects. Nanoparticle eases the drug delivery to the central nervous system via blood brain barrier against the conventional drug delivery. Nanotechnology interact at a molecular level with the biological system and revolutionize the treatment by stimulating, responding to, and interacting with target sites to induce physiological responses while minimizing side effects. This review focuses on current applications of nanomaterials in the therapy and diagnosis of the most common neurodegenerative disorder and highlights the future nanotechnological approaches.

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Keywords

Neurodegenerative disorder, Blood Brain Barrier, Nanoparticles, Nanotechnology.

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