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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1933) Last page : ( 1937)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00348.0

Synthesis, Characterization and Evaluation of Biological Activity of Corn Oil -Based Difatty Acyl Carbamodithioic Acid

Hoidy Wisam H.1,*, Essa Shaimaa M.1, Al-Saady Fouad A.2, Al-Mulla Emad A. Jaffar3

1Chemistry Department, College of Education, University of Al-Qadisiyah, Al-Qadisiyah, Iraq

2College of Pharmacy, Al-Mustansiriyh University, Baghdad, Iraq

3College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, Kufa, Iraq

*Corresponding Author E-mail: wisam.hoidy@qu.edu.iq

Online published on 30 April, 2020.

Abstract

Carbamodithioic acid is a compound derived from thiourea. Thioureas have a significant role in medical chemistry and agriculture because of their biological action as herbicides and rodenticides, also antiviral antibacterial, and antifungal, in addition, anti-HIV and anti-tumor agents and phenoloxidase enzymatic inhibitors. The paper sheds light on Difatty acyl carbamodithioic acid (DFACA) that has antibiotics and antifungal actions that have been made out of corn oil and carbamodithioic acid employing sodium ethoxide as a catalyst. glycerol and Ethyl fatty ester (EFE) are manufactured as secondary products. The synthesis is achieved through refluxing corn oil with carbamodithioic acid in ethanol. In this method, corn oil transformed into about 83% pure DFACA after 10 hrs and a molar ratio of carbamodithioic acid compared to corn oil was 6.0: 1 at 80C. Analysis of elements, 1H nuclear magnetic resonance (NMR) technique and Fourier transform infrared (FTIR) spectroscopy are employed to portray DFACA and EFE. The new compounds (DFACA) was filtered for antimicrobial actions using disc diffusion method for antimicrobial activity against two samples of Gram-positive bacteria and two samples of Gram-negative bacteria represented by "Staphylococcus Aureus and Bacillus Subtilis" and "Escherichia Coli and Klebsiella pneumonia", respectively. Also, examine the effect of DFACA on fungus Candida albicans. The result disclosed that the (DFACA) has high biological activity. The result disclosed that the (DFACA) has high biological action.

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Keywords

Corn oil, Carbamodithioic acid, ethyl fatty ester, antimicrobial, thiourea.

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