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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1895) Last page : ( 1900)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00341.8

New validated analytical methods for the determination of Tavaborole (An anti-fungal agent)

Sheela Avuthu Sai, Annapurna Mukthinuthalapati Mathrusri*, Yasaswini Rangisetty Spandana

GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam-530045, India

*Corresponding Author E-mail: mannapurna.mukthinuthalapati@gitam.edu

Online published on 30 April, 2020.

Abstract

New spectrophotometric methods have been established for the determination of Tavaborole in pharmaceutical formulations. Tavaborole is an antifungal agent used for the fungal infection of nail (onychomycosis). Tavaborole is chemically known as 5 - Fluoro -1,3 - dihydro -2,1-benzoxaborol -1-ol. Tavaborole has shown absorption maxima at 271 nm in all the methods. A calibration curve was drawn by taking the concentration on the X – axis and their respective absorbance on Y – axis for all the methods. Tavaborole obeys Beer-Lambert's law over the concentration range 1–100μg/ml for all the above mentioned methods. The linear regression equations were found to be y = 0.0049x + 0.0017(R2 = 0.9999) and all the methods are validated as per ICH guidelines.

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Keywords

Tavaborole, Spectroscopy, Phosphate buffer, Borate buffer, Validation.

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