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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1861) Last page : ( 1866)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00335.2

Development and Evaluation of Neem Gel Formulation using Gum Karaya as Gelling Agent

Hanh Nguyen Duc*, Thinh Le Van, Duong Do Quang

Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam

*Corresponding Author E-mail: duchanh@ump.edu.vn

Online published on 30 April, 2020.


The aim of this study was to develop and evaluate the neem gel formulation using gum karaya as a gel forming agent. The gelling ability of gum karaya and its mixtures with the other gel-forming agents (sodium alginate, carboxymethyl starch and hydroxypropyl methylcellulose) were demonstrated by rheology properties. Gum karaya was demonstrated to be a gel-forming agent with the pseudoplastic flow. Of three gelling agents, sodium alginate was selected as the best combined excipient with gum karaya due to the better elasticity improvement of the gum karaya gel in comparison with hydroxypropyl methylcellulose (HPMC) and carboxymethyl starch (CMS). The cause-effect relations between the three independent variables (the ratios of gum karaya, calcium chloride and sodium alginate) and the two dependent variables (spreadability and viscosity of neem gel) were investigated. The optimal neem gel formulation comprised gum karaya, calcium chloride and sodium alginate with the concentrations of 1.6%, 0.0435% and 1%, respectively. The optimal neem gel was evaluated for its various properties such as pH, homogeneity, spreadability, active compound quantitation by high performance liquid chromatography (HPLC) and dynamic viscoelasticity behaviours. This study has reported for the first time the application of gum karaya in neem gel preparation. The results of the research may provide the useful data for further studies not only on the gum karaya as the gelling agent but also on the neem gel preparation for the treatment of skin diseases.



Gum Karaya, Gel, Rheology, Neem, optimization.


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