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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1839) Last page : ( 1842)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00331.5

Study of Liver Function and Lipid Profile Changes in Iraqi Cirrhotic patients

Murtadha Jinan Hussein*, Hashim Iman, Razzaq Abdul

Department of Chemistry, College of Science for Women, University of Baghdad, Iraq

*Corresponding Author E-mail: jinanalmosawi@gmail.com

Online published on 30 April, 2020.

Abstract

Cirrhosis is a complication of many liver disease characterized by abnormal structure and function of the liver. The aim of this study is to investigate the liver function levels by measuring Glutamate Oxaloacetate Transaminase (GOT), Glutamate Pyruvate Transaminase (GPT), Alkaline Phosphatase (ALP) and total protein (T.P) and lipid profile levels by measuring total cholesterol (TC), triglyceride (TG), low density lipoproteins (LDL) and high density lipoproteins (HDL). Seventy five individuals of Iraqi adults (25 female and 50 male) were divided into two groups: 25 normal individuals (10 female and 15 male) as control group (group1), their age range (28–60) year and 50 cirrhotic patients (20 female and 30 male), their age range (18–68) year and (35–72) year respectively (group 2). In the present study, the mean value of GOT, GPT and ALP activity were significantly higher in patients with cirrhosis disease than healthy group (p 0.01), while the mean value of T.P. level was 6.21g/dl in cirrhotic patients compared with healthy group 7.54g/dl. The findings indicate that serum (TC, TG, HDL and LDL) levels were significantly decreased (P 0.01) in cirrhotic Patients compared with healthy group. The results also indicate a positive correlation between GOT and GPT, and between ALP and both (GOT, GPT). Also, there was a positive correlation between TC and (TG, HDL and LDL) and between TG and both (HDL, LDL). This study has shown that a significant difference (P 0.05) between male and female in the mean value of T.P and TC levels and also the effect of duration of disease on Parameters was studied.

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Keywords

Cirrhosis, Dyslipidemia, Liver Function tests.

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