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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1801) Last page : ( 1805)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00324.8

Formulation and Evaluation of Vildagliptin Beads by Emulsion Gelation Method

Rajam Radhika Parasuram*, Balaji Aswini, Shanmugam Karthi Raja A, Palanichamy Vishnu Kumar

Department of Pharmaceutics, The Erode College of Pharmacy and Research Institute, Erode, Tamilnadu, India

*Corresponding Author E-mail: radhi_kannan2005@yahoo.co.in

Online published on 30 April, 2020.

Abstract

The objective of the present study was formulation and evaluation of sustained release dosage form of Vildagliptin sodium alginate beads. Vildagliptin is an anti-diabetic drug of the new di-peptidyl peptidase-4 inhibitor class of drug. Vildagliptin is one of the emerging short acting drugs, so the developed formulations provide the advantage of sustained release formulations. Vildagliptin gel beads were prepared by Emulsion gelation method, using sodium alginate and castor oil. Three different formulations (F1, F2, and F3) were prepared by using the drug: polymer ratio as 1:1, 1:2, and 1:3respectively. The gel beads containing oil were prepared by gentle mixing or homogenizing oil and water phase containing sodium alginate and the mixture were then extruded into calcium chloride solution to 6produce the gel beads. F2 was the optimized formulation and further studies were done. The surface morphology and the other characteristic studies such as size analysis and distribution, swelling index, Buoyancy studies and the In-vitro studies were studied. The oil entrapped calcium alginate gel beads showed sustained release. Scanning electron photomicrographs showed the minute oil globules on the surface of the beads.

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Keywords

Vildagliptin, Sodium alginate, Emulsion gelation method, Scanning electron microscopy, Calcium Chloride.

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