Evaluation of Anticonvulsant and Antioxidant Activity of Flacourtia indica on Pentylenetetrazole (PTZ) Induced Convulsions in Mice
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To evaluation of anticonvulsant and antioxidant activity of Flacourtia indica on Pentylenetetrazole (PTZ) induced convulsions in mice
Present study animals are divided into 4 groups of albino mice (n=6) were used. The First group was received as control, second group as standard (diazepam, 4mg/kg); third to fifth groups were treated with ethanol extract Flacourtia indica (100, 200 and 400mg/kg). After 30 min of administration ethanolic extract of Flacourtia indica, in mice I. P injection of PTZ (75mg/kg). Anticonvulsant activity was determined by measuring the Latency, Jerky movements, Straub's tail, Clonic convulsions and Death/Recovery of animals in PTZ induced convulsions in mice.
In PTZ model, Flacourtia indica ethanolic extract at a dose of 400mg/kg prolonged latency and onset to seizure activity compared to 100 and 200 mg/kg.
Flacourtia indica possess anticonvulsant effect as they delay the latency of seizures produced by PTZ.
Flacourtia indica, Anticonvulsant, Anti-oxidant, Diazepam, Pentylenetetrazole.