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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1762) Last page : ( 1766)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00318.2

Evaluation of Anticonvulsant and Antioxidant Activity of Flacourtia indica on Pentylenetetrazole (PTZ) Induced Convulsions in Mice

Ayyanna C.*, Narmada B., Suresh G., Munaf D., Radha B., Bhavani K., Anitha M.

Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh, India

*Corresponding Author E-mail: ayyannac5@gmail.com

Online published on 30 April, 2020.

Abstract

Aim

To evaluation of anticonvulsant and antioxidant activity of Flacourtia indica on Pentylenetetrazole (PTZ) induced convulsions in mice

Methods

Present study animals are divided into 4 groups of albino mice (n=6) were used. The First group was received as control, second group as standard (diazepam, 4mg/kg); third to fifth groups were treated with ethanol extract Flacourtia indica (100, 200 and 400mg/kg). After 30 min of administration ethanolic extract of Flacourtia indica, in mice I. P injection of PTZ (75mg/kg). Anticonvulsant activity was determined by measuring the Latency, Jerky movements, Straub's tail, Clonic convulsions and Death/Recovery of animals in PTZ induced convulsions in mice.

Results

In PTZ model, Flacourtia indica ethanolic extract at a dose of 400mg/kg prolonged latency and onset to seizure activity compared to 100 and 200 mg/kg.

Conclusion

Flacourtia indica possess anticonvulsant effect as they delay the latency of seizures produced by PTZ.

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Keywords

Flacourtia indica, Anticonvulsant, Anti-oxidant, Diazepam, Pentylenetetrazole.

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