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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 4
First page : ( 1672) Last page : ( 1678)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00303.0

Factors Associated with Neonatal Healthcare-Associated Infections (HAIs) in India: A Protocol for Systematic Review and Meta-analysis

Rani Usha1, Lewis Leslie E.2,*, Kothuri Manohar Sai3, Chawla Kiran4, Godinho Myron Anthony5, Ravishankar N6

1Assistant Professor, Department of Health Innovation, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, India

2Professor and Head of Neonatology Unit, Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

3Senior Resident, Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

4Professor and Head, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

5Research Associate, University of New South Wales (UNSW), Australia

6Associate Professor, Department of Data Sciences, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, India

*Corresponding Author E-mail: leslielewis1@gmail.com

Online published on 30 April, 2020.

Abstract

Introduction

Neonatal healthcare-associated infections (HAIs) is one of the leading causes of preventable neonatal mortality in developing nations. This systematic review aims to critically appraise and consolidate the list of risk factors associated with neonatal HAIs in India.

Materials and Methods

We will conduct electronic medical database searches. Studies in the English language, reporting outbreak/surveillance/risk factor/determinants, reporting HAIs among neonates in India, using CDC or WHO driven diagnosis will be considered for inclusion. Two independent authors will screen the title, abstract and full text of the articles from databases. Articles quality will be assessed using National Heart, Lung and Blood Institute criteria and GRADE method. Narrative synthesis, along with descriptive statistics, adopting a random-effects model for meta-analysis anticipating heterogeneity, will be carried out. If the number of studies is more (>10), we will assess publication bias using the funnel plot and degree of symmetry by Egger's test.

Discussion

The burden of neonatal HAIs in South Asian countries, and India is high. It is one of the leading causes of neonatal mortality. There is a dearth of knowledge related to factors contributing to neonatal HAIs in India. The protocol provides a detailed methodology followed by a precise, appropriate statistical analytics tool to be used.

Systematic review registration

PROSPERO CRD42017072861

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Keywords

Systematic review, Protocol, Neonate, Nosocomial Infection, Healthcare-Associated Infections, India, Determinant, Risk Factor, Epidemiology, NICU.

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