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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1601) Last page : ( 1608)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00290.5

Cell Lines and Animal Models of Psoriasis

Dr. Sumithra M., Majeed A. Mohamed*, Dr. Chitra V

Department of Pharmacology, SRM College of Pharmacy, SRM IST, Kattankulathur-603203

*Corresponding Author E-mail: majeed2905@gmail.com

Online published on 22 April, 2020.

Abstract

Psoriasis common chronic autoimmune systemic inflammatory skin disease. It mostly occurs on the skin of the knees, intergluteal cleft, lumbosacral areas, scalp, gland penis, and elbows. Psoriasis characterized by plaques of thick, scaling skin. The rapid proliferation of skin cells which is caused by the pro-inflammatory agents that are produced by T-lymphocytes results in the formation of dry flakes of skin scales. Potential biomarker such as Western blotting, bioplex assay, immunohistochemistry, ELISA used to identify the disease status. Psoriasis affecting two percent in the world. The pathophysiology of disease activated or sensitized T-lymphocytes infiltrate the skin involving also dermal CD4+ TH1 cells and CD8+ T cells that build up in the epidermis and dermis which chronicle to keratinocytes hyper-proliferation. Previously available medicines like emollients and some keratolytic medicines haven't a favorable role in control burn. But advance treatment like coal tar, methotrexate, retinoid, and cyclosporine is good effect proved from mild to severe psoriasis. Phototherapy treatment currently uses to the emerged situation. In this review reported to psoriasis in-vitro, in-vivo models and treatments.

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Keywords

Psoriasis, Topical therapy, Non-pharmacological therapy.

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