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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1549) Last page : ( 1554)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00281.4

Neuro Pharmacological Review on Obesity

Chitra V., Rini R.*

Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpet-603203

*Corresponding Author E-mail: rininannat95@gmail.com

Online published on 22 April, 2020.

Abstract

Obesity is one of the serious problems of the 21st century and affects nearly 300 million people worldwide. About 13% of the world's adult population and over 41 million children under the age of 5 were overweight or obese. It is believed that the common cause of obesity is due to the imbalance in the homeostatic and hedonic regulation and improper disposition of energy intake due to decrease in physical activity. Recent advances in neurobiology have greatly enhanced our understanding of the neuronal and peripheral factors involved in eating behaviour; for an overview of the functional organization of feeding circuits. The Food and Drug Administration (FDA) has approved five long-term obesity drugs for adults who are obese so far: lorcaserin, phentermine/topiramate, naltrexone/bupropion, Orlistat and liraglutide over the past few years. There is an inadequacy in the selection of accurate animal models and methods to validate the toxicity of drugs to treat obesity. To tackle the growing obesity epidemic and its associated metabolic disorders, there is an urgent need to further decipher the CNS-level molecular mechanisms that lead to the dysregulation in energy homeostasis. This review explains the novel methods which might be the promising tools in the management of obesity in future.

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Keywords

Obesity, Overweight, homeostasis, hedonic regulation, neurobiology, dysregulation.

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