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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1351) Last page : ( 1355)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00249.8

Effect of Cuscuta reflexa extract on Experimentally Induced Hypertension in normal and Streptozotocin Induced Diabetes in Rats

Jadhav G. B.*, Bhure R. R., Mundlod K. N., Pingle A. P.

Department of Pharmacology, MVP's College of Pharmacy, MVP Campus, Gangapur Road, Nashik, Affiliated to S.P. Pune University, (M.S.), India.

*Corresponding Author E-mail: aaryajadhav@rediffmail.com

Online published on 22 April, 2020.

Abstract

Diabetes and hypertension are the major cardiovascular risk factors and is an increasing life-threatening disease around the world. Diabetes and hypertension is leading life threatening diseases over worldwide. Available conventional drugs have lot of side effects and tolerance problem. Herbal medicines are preferred to overcome side effects and tolerance. Aim of this research was investigation effect of Cuscuta reflexa on experimentally induced hypertension in normal and streptozotocin induced diabetes in rats. Objective was to find out the possibilities of use of extract as a supportive/protective medicine and to explore the possible toxicities of cuscuta reflexa in these models. Hypertension was induced by Angiotensin II (150ug/kg, i.p) in rats. Diabetes was induced in rats by administration of streptozotocin (50mg/kg). Animals were divided into various groups and effects of ethanolic extracts of cuscuta reflexa were studied in Ang-II induced hypertension in normal rats and streptozotocin induced diabetic rats. Blood pressure was measured by noninvasive techniques (NIBP) using Power lab, AD instrument, Australia. Effect of extracts was studied on oxidative parameters like SOD, CAT, LOP and NO. Extract of Cuscuta reflexa possess significant antidiabetic activity and antihypertensive activity in experimentally induced hypertension in normal and strepozotocin induced diabetes in rats.

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Keywords

Angiotensin-II, Cuscuta reflexa, Hypertension, oxidative stress.

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