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Research Journal of Pharmacy and Technology
Year : 2020, Volume : 13, Issue : 3
First page : ( 1339) Last page : ( 1345)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2020.00247.4

Mathematical Modelling of Dissolution Kinetics in Dosage forms

I Mohamed Rizwan1, Damodharan N2,*

1Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203

2Department of Pharmaceutics, SRM College Of Pharmacy, SRM Institute of Science and Technology, Kattankulathur-603203.

*Corresponding Author E-mail: damodhan@srmist.edu.in

Online published on 22 April, 2020.

Abstract

Drug delivery is a technique by which the drug substances are administered to attain the therapeutic responses in humans or animals. It is crucial to study about the drug release or dissolution for a new solid dosage form. The prediction of correct data of discharge from the drug in the dissolution using mathematical model, which can help to understand the innovation in drug design and formulation with desired therapeutic efficacy and safety. Generally, the mathematical models are used to determine the release of drug profiles are zero-order kinetic model, first order kinetic model, Korsmeyer-peppas model, Higuchi model, Hopfenberg model, Baker Lonsdale model, Hixson Crowell model and Weibull model. Zero-order model explains the constant releases from the formulation such as transdermal, implantable depot, oral control release, matrix tablet with low solubility and suspension. First-order have explained about the release from the formulation like matrix dissolution controlled release, matrix diffusion controlled release, sustained release. Higuchi model explained the drug has released from matrix type. Hixson Crowell cube root law described the drug release has occurred from the variation in particles diameter of system and in surface area. Korsmeyer-peppas model created the experimental equation to evaluate the both fickian and non-fickian release of drug. From the Higuchi model, the Baker and Lonsdale has improved which describes the drug discharge from the matrices of spherical. The Weibull model defined the drug release from the aggregated fraction of drug ‘m’ at time ‘t’ in solution. Hopfenberg model compares the drug release from surface eroding polymers.

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Keywords

Dissolution, Release kinetics, Release models, Mathematical modelling.

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